生物活性
PD173074是有效的，细胞可渗透的和ATP竞争性的FGFR和VEGFR抑制剂。
Targets
| Target | Value |
| FGFR1 | IC50: ~25nM |
| VEGFR2 | IC50: 100nM-200nM |
| c-Src | IC50: 19.8μM |
| EGFR | IC50: >50μM |
| Insulin Receptor | IC50: >50μM |
| MEK | IC50: >50μM |
| PKC | IC50: >50μM |
化学数据
| 目录号 | A10703 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 523.7 |
| Formula | C28H41N7O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 219580-11-7 |
| Synonyms | PD-173074 |
| SMILES | CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C |
溶解度
| In vitro (25°C) | DMSO | 86 mg/mL (164.22 mM) |
| Water | Insoluble |
| Ethanol | 86 mg/mL (164.22 mM) |
| In vivo | 5% DMSO+corn oil | 14 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.09 mL | 95.47 mL | 190.95 mL |
| 0.5 mM | 3.82 mL | 19.09 mL | 38.19 mL |
| 1 mM | 1.91 mL | 9.55 mL | 19.09 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
*The above data is based on the productmolecular weight 523.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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