生物活性
KW-2449是FLT3、ABl、ABl-T315I和Aurora激酶的多激酶抑制剂。
Targets
| Target | Value |
| FLT3(D835Y) | IC50: 1nM |
| Abl(T315I) | IC50: 4nM |
| FLT3 | IC50: 6.6nM |
| Abl | IC50: 14nM |
| FGFR1 | IC50: 36nM |
| AuroraA | IC50: 48nM |
| JAK2 | IC50: 150nM |
| Kit | IC50: 300nM |
| Src | IC50: 400nM |
| PDGFRα | IC50: 1.7μM |
化学数据
| 目录号 | A10508 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 332.4 |
| Formula | C20H20N4O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1000669-72-6 |
| Synonyms | KW 2449, KW2449 |
| SMILES | C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43 |
溶解度
| In vitro (25°C) | DMSO | 58 mg/mL (174.48 mM) |
| Water | Insoluble |
| Ethanol | 58 mg/mL (174.48 mM) |
| In vivo | 0.5% methylcellulose | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 30.08 mL | 150.42 mL | 300.84 mL |
| 0.5 mM | 6.02 mL | 30.08 mL | 60.17 mL |
| 1 mM | 3.01 mL | 15.04 mL | 30.08 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
*The above data is based on the productmolecular weight 332.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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