BI-4464是具有高度选择性的，ATP竞争性的、PTK2/FAK的抑制剂，其IC50值为17nM。是可用于PROTAC降解剂的一个PTK2配体。
CAS：1227948-02-8
分子式：C28H28F3N5O4
分子量：555.55
纯度：98%
存储：Store at -20°C

Background:

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1]. IC50: 17 nM (PTK2/FAK)[1].

[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.