Pyrindamycin A 吡啶霉素 A 是一种抑制 DNA 合成的抗生素。 Pyrindamycin A 显示出抗鼠白血病的抗肿瘤活性，对小鼠和人肿瘤细胞系具有强烈的细胞毒活性，特别是对抗多柔比星抗性细胞。
CAS：118292-36-7
分子式：C26H26ClN3O8
分子量：543.95
纯度：98%
存储：Store at -20°C

Background:

Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml[1].

[1]. Ishii S, et al. Antitumor activity of pyrindamycins A and B. J Antibiot (Tokyo). 1989 Nov;42(11):1713-7.