Rac-Nedisertib(Rac-M3814)是Nedisertib的外消旋体，为有效的DNA-PK抑制剂，IC50值小于3nM。
CAS：1637542-34-7
分子式：C24H21ClFN5O3
分子量：481.91
纯度：98%
存储：Store at -20°C

Background:

Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of<3 nM[1]. DNA-PK|<3 nM (IC50)

Rac-Nedisertib (Compound 137) potently inhibits DNA-PK, with an IC50 of<3 nM for DNA-PK, 0.5-5 μM for cellular pDNA-PK and 15-25 μM for KV11.1 (hERG, human ether a-go-go related gene) ).[1].

[1]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.