Linifanib(ABT-869)

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Linifanib(ABT-869)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

796967-16-3

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议
10mM * 1mL in DMSO	电议

产品名称

ABT869, ABT-869

产品介绍

生物活性

Linifanib (ABT-869)是一种结构新颖的有效RTK，VEGF和PDGF抑制剂，对人内皮细胞，PDGFR-β，KDR和CSF-1R的IC50分别为0.2、2、4和7 nM。

Targets

Target	Value
VEGFR1/FLT1	IC50: 3nM
CSF-1R	IC50: 3nM
VEGFR2/KDR	IC50: 4nM
FLT3	IC50: 4nM
Kit	IC50: 14nM
PDGFRβ	IC50: 66nM
Tie-2	IC50: 170nM
VEGFR3/FLT4	IC50: 190nM
SGK	IC50: 940nM
RET	IC50: 1.9μM
PKA	IC50: 5.9μM
Cdc2	IC50: 9.8μM
FGFR	IC50: >12.5μM
Lyn	IC50: >20μM
LCK	IC50: 38μM
Src	IC50: >50μM
IGFR	IC50: >50μM
INSR	IC50: >50μM
EGFR	IC50: >50μM
Hck	IC50: >50μM
c-Met	IC50: >50μM
Fyn	IC50: >50μM
FGR	IC50: >50μM
Akt	IC50: >50μM

化学数据

目录号	A10025
作用机制	Inhibitor (抑制剂)
M. Wt	375.4
Formula	C21H18FN5O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	796967-16-3
Synonyms	ABT869, ABT-869
SMILES	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N

溶解度

In vitro (25°C)	DMSO	73 mg/mL (194.45 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG 300+5%Tween80+50%ddH2O	9 mg/mL
<1 mg/ml means slightly soluble or insoluble. Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.64 mL	133.19 mL	266.38 mL
0.5 mM	5.33 mL	26.64 mL	53.28 mL
1 mM	2.66 mL	13.32 mL	26.64 mL
5 mM	0.53 mL	2.66 mL	5.33 mL

*The above data is based on the productmolecular weight 375.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.