DW14800 是一种蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂，IC50 值为 17 nM。DW14800 降低 H4R3me2s 的水平，增强 HNF4α 的转录。抗肿瘤活性。
CAS：2243709-60-4
分子式：C31H36N4O3
分子量：512.64
纯度：98%
存储：Store at -20°C

Background:

DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1]. PRMT5[1]

[1]. Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617.