THIP (Gaboxadol) 是一种选择性 δ-GABAAR 激动剂，功能选择性 GABAAR 配体，对 α4β1δ, α4β3δ 表现出激动作用，对 αβγ 和 α4β2δ GABAARs 表现出弱拮抗作用。
CAS：64603-91-4
分子式：C6H8N2O2
分子量：140.14
纯度：98%
存储：Store at -20°C

Background:

THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1]. α4β3δ GABAAR|13 μM (EC50)

[1]. Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34(49):16256-72.