Tirabrutinib(ONO-4059)hydrochloride的IC50值是2.2nm，是一种有选择性和新颖的抑制剂。在B细胞中ONO-4058结合BTK，因此阻止B细胞受体信号和阻碍B细胞的发展。
CAS：1439901-97-9
分子式：C25H23ClN6O3
分子量：490.94
纯度：98%
存储：Store at -20°C

Background:

Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

[1]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59. [2]. Harriet S et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 2016, 127:411-419.