ML367 是一种 ATPase 家族 AAA 结构域蛋白 5 (ATAD5) 稳定的有效抑制剂，作为一个探针分子，具有低摩尔抑制浓度。ML367 阻断 DNA 的修复通路，抑制一般的 DNA 损伤反应，包括应对紫外照射产生的 RPA32 和 CHK1 的磷酸化。
CAS：381168-77-0
分子式：C19H12F2N4
分子量：334.32
纯度：98%
存储：Store at -20°C

Background:

ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1]. ATAD5[1]

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd[1]. Western Blot Analysis[1] Cell Line: HEK293T cells

[1]. Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program.