GNF351是一种芳基烃受体(AHR)拮抗剂。GNF351与结合到AHR的光亲和性AHR配体竞争，IC50为62nM。GNF351对小鼠或人角质形成细胞的毒性极小。
CAS：1227634-69-6
分子式：C24H25N7
分子量：411.5
纯度：98%
存储：Store at -20°C

Background:

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1]. IC50: 62 nM (aryl hydrocarbon receptor)[1]

GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes[1]. Cell Proliferation Assay[1] Cell Line: Human primary keratinocytes

[1]. van den Bogaard EH，et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.