Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 μM) and a derivative of colchicine.
CAS：2730-71-4
分子式：C22H25NO5S
分子量：415.5
纯度：98%
存储：Store at -20°C

Background:

Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine . It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).