CGP 36742 是一种选择性 GABAB 受体拮抗剂，可在外周给药后穿透血脑屏障，IC50 为 32 μM。CGP 36742 可用于治疗抑郁症。
CAS：123690-78-8
分子式：C7H18NO2P
分子量：179.2
纯度：98%
存储：Store at -20°C

Background:

CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood-brain barrier after peripheral administration, with an IC50 of 32 μM. CGP 36742 is useful in treatment of depression[1]. IC50: 32 μM (GABAB)[1]

[1]. Nowak G, et al. Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol. 2006 Nov;149(5):581-90.