Tefinostat (CHR-2845) 是一种单核细胞/巨噬细胞靶向的 HDAC 广谱抑制剂，通过细胞内酯酶人羧酸酯酶-1 (hCE-1) 切割成活性酸 CHR-2847。具有抗抗单核细胞系白血病活性。
CAS：914382-60-8
分子式：C28H37N3O5
分子量：495.61
纯度：98%
存储：Store at -20°C

Background:

Tefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity[1]. HDAC

[1]. Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7(13):16650-62.