THZ1-R是THZ1的非半胱氨酸反应性类似物，对 CDK7 抑制的活性降低。 THZ1-R与 CDK7 结合的 Kd 为142 nM。
CAS：1621523-07-6
分子式：C31H30ClN7O2
分子量：568.07
纯度：98%
存储：Store at -20°C

Background:

THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM. CDK7|146 nM (IC50)

THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM[1].

[1]. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.