Endovion(NS3728)是一种阴离子通道抑制剂(如氯离子通道)，也是特异性的VRAC/VSOAC阻断剂。Endovion(NS3728)还是一种ANO1抑制剂。
CAS：265646-85-3
分子式：C16H9BrF6N6O
分子量：495.18
纯度：98%
存储：Store at -20°C

Background:

Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2]. Chloride channel, VRAC/VSOAC[1]. ANO1[2].

[1]. S?rensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73. [2]. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.