Arp2/3 complex inhibitor that inhibits actin polymerization
CAS：442633-00-3
分子式：C18H17FN2O
分子量：296.34
纯度：98%
存储：Store at -20°C

Background:

CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1].

参考文献:
[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.