PD-159020是一种非选择性的ETA/ETB拮抗剂，对hETA和hETB的IC50值分别为30和50nM。
CAS：177904-00-6
分子式：C32H25NO8
分子量：551.54
纯度：98%
存储：Store at -20°C

Background:

PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively.

PD-159020 demonstrates excellent inhibition of arachidonic acid release, AAR-B, with an IC50 of 0.23 μM.

[1]. Amy Mbunker, et al. 1,3-diaryl-2-carboxyindoles as potent non-peptide endothelin antagonists. Bioorganic & Medicinal Chemistry Letters. Volume 6, Issue 9, 7 May 1996, Pages 1061-1066