LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.
CAS：1879887-96-3
分子式：C24H18N2O3S
分子量：414.48
纯度：98%
存储：Store at -20°C

Background:

LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.

LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 uM for PI3K β and δ, respectively. LTURM34 shows potent and broad ranging antiproliferative activity. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line[1].

参考文献:
[1]. Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39.