JHU-083 选择性地阻断脑 CD11b+ 细胞中的谷氨酰胺酶 (glutaminase) 活性。谷氨酰胺拮抗剂 JHU-083 在实验性脑疟疾 (ECM) 中可阻断谷氨酰胺酶，导致动物中谷氨酸水平的净降低。
CAS：1998725-11-3
分子式：C14H24N4O4
分子量：312.36
纯度：98%
存储：Store at -20°C

Background:

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2]. Glutamine[2]

[1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. [2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.