| CAS NO: | 832115-62-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 234.27 |
|---|---|
| Formula | C11H10N2O2S |
| CAS No. | 832115-62-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 46 mg/mL (196.4 mM) |
| Water: <1 mg/mL | |
| Ethanol: 13 mg/mL (55.5 mM) | |
| Solubility (In vivo) | 5% DMSO+55% PEG 300+ddH2O: 10mg/mL |
| Synonyms | ISX-9; ISX 9; ISX9; Isoxazole 9; Isoxazole-9 |
| In Vitro | In vitro activity: In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. Cell Assay: Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells. |
|---|---|
| In Vivo | In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. |
| Animal model | Transgenic Nkx2.5-luciferase reporter mice |
| Formulation & Dosage | Formulated in 30 % (2-hydroxypropyl)-β-cyclodextrin; 20 mg/kg; i.p. injection |
| References | PLoS One. 2015 Sep 25;10(9):e0138724; FASEB J. 2012 Aug;26(8):3148-62. |
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