Diphenhydramine HCl is a potent and first-generation histamine H1 receptor antagonist and an antiemetic that is used in various allergic conditions such as rhinitis, urticaria and conjunctivitis. Diphenhydramine blocks tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents with K(d) values of 48 mM and 86 mM, respectively, at a holding potential of -80 mV. Diphenhydramine shifts the conductance-voltage curve for TTX-S sodium currents in the depolarizing direction but has little effect on that for TTX-R sodium currents.

纯度：≥98%

CAS：58-73-1