PF-05105679 is a novel, orally bioactive and selective TRPM8 Antagonist (IC50 = 103 nM) with clinical potential for cold-related pain. The transient receptor potential (TRP) family of ion channels comprises nonselective cation channels that respond to a wide range of chemical and thermal stimuli. TRPM8, a member of the melastatin subfamily, is activated by cold temperatures (<28 °C), and antagonists of this channel have the potential to treat cold induced allodynia and hyperalgesia.

纯度：≥98%

CAS：1398583-31-7