| CAS NO: | 12650-69-0 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 500.62 |
|---|---|
| Formula | C26H44O9 |
| CAS No. | 12650-69-0 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 100 mg/mL (199.8 mM) |
| Water: 46 mg/mL warmed (91.9 mM) | |
| Ethanol: 100 mg/mL (199.8 mM) | |
| Solubility (In vivo) | Chemical Name: 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid InChi Key: MINDHVHHQZYEEK-HBBNESRFSA-N InChi Code: InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1 SMILES Code: O=C(O)CCCCCCCCOC(/C=C(C)/C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@H]([C@@H](O)C)C)[C@@H](O)[C@H]1O)=O |
| Synonyms | BRL4910A; Pseudomonic acid; BRL-4910A; BRL 4910A; Mupirocin, Bactroban, Centany |
| In Vitro | In vitro activity: Mupirocin (BRL-4910A) shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin (BRL-4910A) is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum |
|---|---|
| In Vivo | Mupirocin is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A |
| Animal model | N/A |
| Formulation & Dosage | |
| References | [1]. Sutherland R, et al. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother. 1985 Apr;27(4):495-8. [2]. Parenti MA, et al. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6(10):761-70. |
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