| CAS NO: | 1037184-44-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 366.20 |
|---|---|
| Formula | C17H13Cl2NO4 |
| CAS No. | 1037184-44-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 73 mg/mL (199.3 mM) |
| Water: <1 mg/mL | |
| Ethanol: 51 mg/mL (139.3 mM) | |
| Other info | Chemical Name: 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-one InChi Key: HLXSCTYHLQHQDJ-UHFFFAOYSA-N InChi Code: InChI=1S/C17H13Cl2NO4/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22) SMILES Code: O=C1NC2=C(C(Cl)=CC=C2Cl)C1(O)CC(C3=CC=C(OC)C=C3)=O |
| Synonyms | YK-4-279; YK-4279; YK4279; YK4-279; YK 4-279; YK 4279. |
| In Vitro | In vitro activity: YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion |
|---|---|
| In Vivo | In vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors. |
| Animal model | Nude mice bearing prostate cancer PC3, TC71 or CHP-100 xenografts |
| Formulation & Dosage | Dissolved in DMSO; 1.5 mg/dose; i.p. injection |
| References | Nat Med. 2009 Jul;15(7):750-6; PLoS One. 2014 Dec 5;9(12):e114260. |
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