AM-2394 is a novel, potent and selective Glucokinase activator/agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good orally bioavailable bioavailability in multiple animal models, and lowers glucose excursion following an orally bioavailable glucose tolerance test in an ob/ob mouse model of diabetes.

纯度：≥98%

CAS：1442684-77-6