Vesnarinone (OPC-8212) is a quinolinone-based cardiotonic agent, acting as a mixed phosphodiesterase 3 (PDE3) inhibitor and ion-channel modifier with modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure. Vesnarinone is also a novel cytokine inhibitor with the potential to be used for the treatment of lung fibrosis. Vesnarinone inhibits BLM-induced pulmonary fibrosis, at least in part, by the inhibition of acute lung injuries in the early phase.

纯度：≥98%

CAS：81840-15-5