VU661013 is a novel and potent MCL-1 Inhibitor combining with Venetoclax for rescuing Venetoclax Resistant Acute Myelogenous Leukemia. VU661013 is a potent, selective MCL-1 inhibitor that de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML, and is active in venetoclax-resistant cells and patient derived xenografts. In addition, VU661013 was safely combined with venetoclax for synergy in murine models of AML.

纯度：≥98%

CAS：2131184-57-9