| CAS NO: | 184475-71-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 319.72 |
|---|---|
| Formula | C15H11ClFN3O2 |
| CAS No. | 184475-71-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO:>20 mg/mL |
| Water: N/A | |
| Ethanol: N/A | |
| Chemical Name | 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol; 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol |
| Synonyms | FAAH-IN-2; O-Desmorpholinopropyl Gefitinib; JLVTVCRXFMLUIF-UHFFFAOYSA-N InChi Key: JLVTVCRXFMLUIF-UHFFFAOYSA-N InChi Code: InChI=1S/C15H11ClFN3O2/c1-22-14-6-12-9(5-13(14)21)15(19-7-18-12)20-8-2-3-11(17)10(16)4-8/h2-7,21H,1H3,(H,18,19,20) |
| SMILES Code | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)O |
| In Vitro | In vitro activity: FAAH-IN-2 is a novel and potent FAAH (fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2. It is also named as O-Desmorpholinopropyl Gefitinib and is a metabolite of gefitinib, which is an EGFR inhibitor. FAAHs (also known as EC 3.5.1.99, oleamide hydrolase, anandamide amidohydrolase) are a family of enzymes that belong to serine hydrolases. In humans, the family is represented by FAAH 1 and 2. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | J Thorac Oncol. 2018 Oct;13(10):e211-e214; WO/2008/100977A2. |
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