JH-XI-10-02 is a novel, potent and selective PROTAC-based degrader of CDK8, with an DC50 of 159 nM for degradation of CDK8 in Jurkat cells. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.

纯度：≥98%

CAS：2209085-22-1