Inobrodib (CCS1477; BP-IN-1; CCS-1477) is a novel, potent and selective p300/CBP bromodomain inhibitor with anticancer activity. The combination of CCS-1477 and JQ1 resulted in a highly synergistic inhibitory effect on proliferation in normal 22Rv1 cells. Inobrodib (CCS1477) inhibits p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM.

纯度：≥98%

CAS：2222941-37-7