| CAS NO: | 1493764-08-1 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 463.58 |
|---|---|
| Formula | C25H33N7O2 |
| CAS No. | 1493764-08-1 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 292 mg/mL (198.5 mM) |
| Water: <1 mg/mL | |
| Ethanol: 5 mg/mL (10.8 mM) | |
| Other info | Chemical Name: N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide InChi Key: NPVXOWLPOFYACO-XUTJKUGGSA-N InChi Code: InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)/t19-,21- SMILES Code: O=C(C1=CN=C(NCCCC)N=C1N[C@H]2CC[C@H](O)CC2)NCC3=CC=C(N4C=CN=C4)C=C3 |
| Synonyms | UNC-2881, UNC 2881, UNC2881, |
| In Vitro | In vitro activity: UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation. Kinase Assay: UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Cell Assay: In 697 B-ALL cells, UNC2881 inhibited Mer phosphorylation with IC50 value of 22 nM. Also, UNC2881 inhibited ligand-dependent phosphorylation of a chimeric protein consisting of the intracellular domain of Mer and the extracellular domain of the epidermal growth factor receptor (EGFR). In human platelet-rich plasma, UNC2881 inhibited platelet aggregation induced by fibrillar Type I equine collagen by greater than 25%. UNC2881 also inhibited ATP release, a marker of platelet activation. |
|---|---|
| In Vivo | UNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice. |
| Animal model | Mouse model |
| Formulation & Dosage | 94.5 mL/min/kg; oral |
| References | J Med Chem. 2013 Dec 12;56(23):9693-700. |
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