Kira8 (AMG18; Kira-8; AMG-18) is a potent and allosteric inhibitor of IRE1α kinase-inhibiting rnase attenuator (kira) with antifibrotic effects. It allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. It can promote reversal of established fibrosis.

纯度：≥98%

CAS：1630086-20-2