Milademetan (DS-3032b; DS3032; DS-3032) is a potent, selective and orally bioactive MDM2 inhibitor with potential antitumor activity. DS-3032b binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.

纯度：≥98%

CAS：1398568-47-2