Aristolactam I (AL-I) is a major metabolite of aristolochic acid I (AA-I), and is able to form DNA adducts, thus causing renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway.

纯度：≥98%

CAS：13395-02-3