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AZD-9291(Osimertinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD-9291(Osimertinib)图片
CAS NO:1421373-65-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
AZD 9291, AZD9291
产品介绍

生物活性

AZD-9291 (Osimertinib)是第三代EGFR抑制剂,在临床前研究中显示出希望,并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。

靶点信息

L858R/T790M EGFR (LoVo cells)Exon 19 deletion EGFR (LoVo cells)WT EGFR (LoVo cells)
11.44 nM12.92 nM493.8 nM

化学数据

目录号A13681
作用机制Inhibitor (抑制剂)
M. Wt499.61
FormulaC28H33N7O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1421373-65-0
SynonymsAZD 9291, AZD9291
SMILESCN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

溶解度

In vitro (25°C)DMSOWarmed: 90 mg/mL (180.14 mM)
WaterInsoluble
EthanolWarmed: 39 mg/mL (78.05 mM)
In vivo5%DMSO+40%PEG300+5%Tween80+50%ddH2O7.1 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.02 mL100.08 mL200.16 mL
0.5 mM4 mL20.02 mL40.03 mL
1 mM2 mL10.01 mL20.02 mL
5 mM0.4 mL2 mL4 mL

*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.