| CAS NO: | 1357302-64-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 225.29 |
|---|---|
| Formula | C15H15NO |
| CAS No. | 1357302-64-7 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 45 mg/mL (199.7 mM) |
| Water: <1 mg/mL | |
| Ethanol: 45 mg/mL (199.7 mM) | |
| Solubility (In vivo) | 1% DMSO+30% polyethylene glycol+1% Tween 80: 20 mg/mL |
| Synonyms | OGL002; OGL 002; OG-L002 Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol InChi Key: DSOJSZXQRJGBCW-CABCVRRESA-N InChi Code: InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m1/s1 SMILES Code: OC1=CC(C2=CC=C([C@@H]3[C@@H](N)C3)C=C2)=CC=C1 |
| In Vitro | In vitro activity: OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene Kinase Assay: OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene Cell Assay: HeLa or HFF cells are treated with the indicated concentrations of saponin (positive control) or compound OG-L002 for 12 hours. Cytotoxicity is determined using conditions recommended by the manufacturer and expressed as ratios to the cytotoxicity of the DMSO control. |
|---|---|
| In Vivo | OG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model. |
| Animal model | BALB/c female mice are infected with HSV-2 (strain MS). |
| Formulation & Dosage | Dissolved in DMSO; 50 mg/kg; i.p. |
| References | Nature. 2012 Aug 16;488(7411):404; Trends Cell Biol. 2010 Nov;20(11):662-71. |
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