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LEE011(Ribociclib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LEE011(Ribociclib)图片
CAS NO:1211441-98-3
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品名称
LEE-011, LEE 011
产品介绍

生物活性

LEE011 (Ribociclib)是一种可口服的细胞周期蛋白依赖性激酶(CDK)抑制剂,靶向细胞周期蛋白D1/CDK4和细胞周期蛋白D3/CDK6细胞周期途径,具有潜在的抗肿瘤活性。

靶点信息

CDK4 (Cell-free assay)CDK6 (Cell-free assay)

化学数据

目录号A13549
作用机制Inhibitor (抑制剂)
M. Wt434.54
FormulaC23H30N8O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1211441-98-3
SynonymsLEE-011, LEE 011
SMILESCN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5

溶解度

In vitroDMSO7 mg/mL (16.1 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.01 mL115.06 mL230.13 mL
0.5 mM4.6 mL23.01 mL46.03 mL
1 mM2.3 mL11.51 mL23.01 mL
5 mM0.46 mL2.3 mL4.6 mL

*The above data is based on the productmolecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.