Description: T-448 is a novel,orally-bioactive, specific and irreversible (covalent) inhibitor of lysine-specific demethylase 1 (LSD1) which is an H3K4 demethylase, with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons. It can improve learning function without causing thrombocytopenia in mice.

References: T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice. Neuropsychopharmacology. 2018 Dec 22.

纯度：≥98%

CAS：1597426-52-2