Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 also available.

151804-79-4

C122H196N40O39

2847.11

AC 253

H2O:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years