C16-PAF (PAF (C16)) 是一种磷脂介质，是一种血小板活化因子和 PAF G 蛋白偶联受体 (PAFR) 的配体。C16-PAF 具有抗细胞凋亡作用，并通过激活 PAFR 来抑制 Caspase 依赖性死亡。C16-PAF 是一种有效的MAPK和MEK/ERK激活剂。C16-PAF 诱导血管通透性增加。

C16-PAF (PAF (C16)) is a phospholipid mediator that is a platelet-activating factor and ligand for PAF G-protein-coupled receptor ( PAFR ). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability [1] [2] [3] [4] [5].

C16-PAF (PAF (C16); 0.5-1.5 μM; for 24 hours) causes significant concentration-dependent neuronal loss in PAFR / but not PAFR +/+ cultures. C16-PAF (1 μM) elicits neuronal death in PAFR / cells infected with EGFP alone [1]. C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3 in PAFR / neurons [1]. C16-PAF is synthesized by two distinct pathways; the remodeling pathway and the de novo synthesis pathway. C16-PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor [2] [3]. C16-PAF (1-25 μg/ml; 6, 12, 24 h) inhibits M. smegmatis and M. bovis BCG growth in a time-dependent manner [3]. Cell Viability Assay [1] Cell Line: Cerebellar granule neurons (CGNs) from PAFR / and PAFR +/+ mice Concentration: 0.5-1.5 μM Incubation Time: 24 hours Result: Elicited significant concentration-dependent neuronal loss in PAFR / but not PAFR +/+ cultures in serum-free media. Western Blot Analysis [1] Cell Line: CGNs Concentration: 1 μM Incubation Time: 24 hours Result: Activated caspase 7 but not caspase 3 in PAFR / neurons.

74389-68-7

C26H54NO7P

523.68

PAF (C16)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years