AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).

AR-A 2 (AR-A000002) is a selective 5-HT1B receptor antagonist and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor. AR-A 2 also binds to the rat cortical 5HT1B/1D receptor (Ki: 20 nM), rat cortex 5-HT2A receptor (Ki: 339 nM), rat hippocampus 5-HT1A receptor (Ki: 3070 nM). In addition, AR-A 2 also exhibits an affinity for dopamine D2 (Ki: 330 nM) and α1-adrenoceptors (Ki: 490 nM).

220051-79-6

C27H36N4O2

448.6

AR-A 000002;AR-A 2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years