hCA XII/II/IX-IN-1 (Compound 3) 是一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA I、 hCA II、hCA IX 和 hCA XII 的IC50分别为 2.6、0.004、0.005 和 0.001 μM。hCA XII/II/IX-IN-1 具有抗癌活性。

hCA XII/II/IX-IN-1 (Compound 3) is a potent human carbonic anhydrase (hCA) inhibitor with IC 50 values of 2.6, 0.004, 0.005 and 0.001 μM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA XII/II/IX-IN-1 shows anticancer activity [1].

hCA XII/II/IX-IN-1 (Compound 3) shows inhibitory activity against HT-29 normoxia, HT-29 hypoxia, MDA-MB-231 normoxia and MDA-MB-231 hypoxia cells with IC 50 values of 1.71 ± 0.24, 0.65 ± 0.033, 17.56 ± 0.99 and 1.92 ± 0.11 μM, respectively [1].

C25H34N4O7S

534.63

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years