(2-Hydroxypropyl)-β-cyclodextrin 是一种药物递送载体，可提高稳定性和利用度。

(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve stability and bioavailability.

Cell treatment with (2-hydroxypropyl)-β-cyclodextrin can activate the activation of the transcription factor EB (the main regulator of lysosomal function and autophagy) and enhance the cell's autophagy clearance ability[1]. (2-Hydroxypropyl)-β-cyclodextrin treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for (2-Hydroxypropyl)-β-cyclodextrin after 72 hours exposure are in the range of 3.86–10.09 mM. (2-Hydroxypropyl)-β-cyclodextrin also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by (2-Hydroxypropyl)-β-cyclodextrin[2].

Intraperitoneal injection of (2-Hydroxypropyl)-β-cyclodextrin significantly improves survival in leukemia mouse models. Systemic administration of (2-Hydroxypropyl)-β-cyclodextrin to mice has no significant adverse effects[2].

128446-35-5

C63H112O42

1541.547

HP-β-CD;羟丙基-β-环糊精;羟丙基-BETA-环糊精;Hydroxypropyl-β-cyclodextrin;Hydroxypropyl betadex;(2-Hydroxypropyl)-β-cyclodextrin

DMSO:150 mg/mL
H2O:50 mg/mL,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years