Naratriptan hydrochloride是一种5-HT1受体激动剂，有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用，从而减少促炎神经肽的释放。

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.

143388-64-1

C17H26ClN3O2S

371.92

盐酸那拉曲坦;Naratriptan HCl;GR-85548A hydrochloride;Naramig;Amerge

H2O:20 mg/mL (53.8 mM)
DMSO:69 mg/mL (185.5 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years