2-(Methylamino)-1H-purin-6(7H)-one 是一种在人体体液中发现的内源性甲基化核苷,是一种修饰的核苷。
产品描述
2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.
体外活性
2-(Methylamino)-1H-purin-6(7H)-one is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[1]. 2-(Methylamino)-1H-purin-6(7H)-one is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[2].
Cas No.
10030-78-1
分子式
C6H7N5O
分子量
165.15
别名
6-羟基-2-氨甲基嘌呤;N2-methylguanine
储存和溶解度
DMSO:< 1 mg/mL (insoluble or slightly soluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years