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5-Ethynyl-2'-deoxyuridine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-Ethynyl-2'-deoxyuridine图片
CAS NO:61135-33-9
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品介绍
5-Ethynyl-2'-deoxyuridine 是一种属于 ALKyl chain 类的 PROTAC linker,可用于 PROTAC 的合成分子。它是一种胸腺嘧啶核苷类似物,在细胞增殖时能够插入正在复制的 DNA 分子中, EdU 与染料的共轭反应可以进行高效快速的细胞增殖检测分析。

产品描述

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine that is used to monitor de novo DNA synthesis through click chemistry.It is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

体外活性

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].Like 5-bromo-2’-deoxyuridine (BrdU), EdU is incorporated into DNA during active DNA synthesis. It can then be detected using a fluorescent azide probe and copper catalysis using 1,3-dipolar cycloaddition.Modified nucleosides, including EdU, can be cytotoxic when added to cells for prolonged periods[2].5-Ethynyl-2'-deoxyuridine (EdU) staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system[3]

Cas No.

61135-33-9

分子式

C11H12N2O5

分子量

252.22

储存和溶解度

H2O:25 mg/mL (95.15 mM),Need ultrasonic
DMSO:120 mg/mL (475.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years