Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.

110084-95-2

C148H221N41O47S

3358.68

des-His1-[Glu9]-Glucagon (1-29) amide

H2O:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years