5-HT2B antagonist-1 是一种具有口服活性的5-HT2B受体拮抗剂，IC50值为 33.4 nM。5-HT2B antagonist-1可用于以 5-HT2B 受体信号传导为特征的疾病研究，如肝细胞癌、心血管疾病或胃肠道疾病。

5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC 50 of 33.4 nM. It can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease [1] [2].

5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC 50 values ranging from 12.6 to 57.5 μM [1]. 5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines [3].

5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) significantly reduces visceral hypersensitivity in irritable bowel syndrome (IBS) rats [2].

393129-91-4

C11H14BrN5

296.17

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years