Tenofovir(GS 1278)

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Tenofovir(GS 1278)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	147127-20-6
规格:	≥98%

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议
250mg	电议
500mg	电议
1g	电议
2g	电议
5g	电议
10g	电议

产品介绍

Tenofovir (formerly also known as GS-1278; PMPA; TDF) is an approved anti-HIV drug that blocks reverse transcriptase and hepatitis B virus infections. Tenofovir is an antiretroviral medication used to prevent and treat HIV/AIDS and to treat chronic hepatitis B. Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir is the active substance of tenofovir disoproxil which is a prodrug that is used because of its better absorption in the gut.

理化性质和储存条件

Molecula Formula: C9H14N5O4P
Exact Mass: 287.0783
Molecular Weight: 287.2158
Elemental Analysis: C, 37.64; H, 4.91; N, 24.38; O, 22.28; P, 10.78

Related CAS #: 202138-50-9 (fumarate); 206184-49-8 (hydrate); 379270-37-8 (alafenamide); 206184-49-8 (hydrate); 1571075-19-8 (aspartate); 201341-05-1 Tenofovir dsoproxil); 1236287-04-9 (Tenofovir maleate); 1392275-56-7 (Tenofovir alafenamide hemifumarate); 379270-38-9 (Tenofovir alafenamide fumarate); 1464851-21-5 [(Z)-9-Propenyladenine; (Z)-Mutagenic Impurity of Tenofovir Disoproxil]; 1446486-33-4 [9-Propenyladenine; Mutagenic Impurity of Tenofovir Disoproxil; Tenofovir Impurity 2];

Synonym: GS 1278; GS1278; GS-1278; PMPA; TDF; GS1275; GS-1275; GS 1275; Tenofovir; TFV gel; PMPA

Chemical Name: (R)-(((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid

InChi Key: SGOIRFVFHAKUTI-ZCFIWIBFSA-N

InChi Code: InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1

SMILES Code: C[C@@H](OCP(O)(O)=O)CN1C=NC2=C(N)N=CN=C12